Contr. U.S. Natl. Herb. 8: 19. 1903
Phenology: Flowering summer–late summer, rarely in spring; fruiting late summer–early fall.
Habitat: Glades and open woods, on rocky and sandy soils, often on slopes
Elevation: 0–600 m
Ala., Ark., Fla., Ga., Ill., Ind., Ky., La., Miss., Mo., N.C., Ohio, Okla., S.C., Tenn., Tex., Va., W.Va., Mexico (Nuevo León, Tamaulipas).
Leaf shape and size in Manfreda virginica vary with soil type, amount of shade, length of cold period, and position of leaf in the rosette. Speckles and spots occur frequently on some leaves in most populations, and some authors have used the informal designation “forma tigrina” for such variants. Pollination is primarily by sphinx moths (S. E. Verhoek 1978).