Plants 4–7.5(–10) dm, finely pubescent. Stems sparingly branched. Leaves 5–15 × 2–5 cm; blade ovate to oblanceolate, rounded basally, adaxial surface glabrate or veins moderately pubescent, abaxial surface lanulose, densely so on veins, margins short-pubescent, hairs uniform, pointed sharply forward, apex narrowly acuminate. Flowers 1–3; perianth turbinate, narrowed basally; tepals spreading, greenish white to greenish yellow, linear-lanceolate to linear-elliptic, 15–22 mm, apex long-acuminate; stamens included, 8–15 mm; filaments narrowly dilated basally, 6–12 mm; anthers 2–4 mm, glabrous; ovary narrowly ellipsoid, glabrous, ovules 2 per locule, pendulous; style stout, 8–12 mm, glabrous; stigma weakly 3-lobed. Berries bright red, 1–2(–4)-seeded, globose, 10–15 mm, glabrous. Seeds 5–6 mm. 2n = 18.
Phenology: Flowering late spring–early summer.
Habitat: Rich moist, deciduous woods, coves
Elevation: 200–1600 m
Ont., Ala., Ark., Ga., Ky., Md., N.Y., N.C., Ohio, Pa., S.C., Tenn., Va., W.Va.
Recent collections have extended the known range of Prosartes lanuginosa from the unglaciated Appalachians to the other ancient, eastern North American upland, the Ozark Mountains of Arkansas.