Herbage glabrous, sometimes sparsely stipitate-glandular, not resinous. Leaf blades narrowly oblong to narrowly oblanceolate, 20–50 mm, margins shallowly to deeply pinnatifid (lobes in 3–8 evenly arranged pairs, apically aristate). Involucres 7–8 × 5–7.5 mm. Phyllary apices green to greenish yellow, not aristate, sparsely to prominently gland-dotted, without resin pockets. Florets 18–25; corollas 5–6 mm. Cypsela ribs not forming apical hornlike extensions.
Phenology: Flowering Jul–Sep.
Habitat: Slopes, river edges, sandy to clay soils, gypseous or saline, badlands in pinyon-juniper woodlands, commonly with Atriplex
Elevation: 1500–1800 m
Isocoma azteca is similar to I. rusbyi in most features and perhaps most closely related to it; the pinnate leaves of I. azteca are distinctive. The two taxa are essentially contiguous in range along the New Mexico-Arizona border and their interaction in natural populations needs to be studied.